Applications

 

Fluidity One-M is designed for in-solution characterization of biomolecular interactions across a wide range of research and development settings. By combining Microfluidic Diffusional Sizing (MDS) with low sample consumption, rapid assay workflows, and multiparametric readouts, the platform supports measurement of hydrodynamic size, binding affinity (KD), active concentration, and stoichiometry in native and complex sample environments. The instrument is positioned for applications spanning membrane proteins, serum antibodies, protein aggregates, antibody engineering, and biomolecular condensates.

  • Membrane ProteinsPurification-free analysis of target concentration and ligand affinity in native-like membrane preparations.
  • SerologyDirect measurement of antibody affinity and concentration in serum or plasma.
  • Amyloid BiologyIn-solution profiling of antibody binding to monomers, oligomers, and fibrils
  • Antibody EngineeringQuantitative Fc receptor binding analysis for Fc optimization and half-life engineering.
  • RNA & LLPSMeasurement of RNA compaction, peptide binding, and condensate formation in solution.